Moeli oa Theknoloji oa Glutaraldehyde: Katleho e Kholo Theknolojing ea Khahlanong le Calcification

Lefapheng la ho kenya di-implant tsa pelo le methapo ya madi, glutaraldehyde e se e sebedisetswa ho phekola dinama tsa diphoofolo (jwalo ka pericardium ya dikgomo) bakeng sa tlhahiso ya di-valve tsa bioprosthetic. Leha ho le jwalo, dihlopha tse setseng tsa aldehyde tse lokolohileng tse tswang ditshebetsong tsa setso di ka lebisa ho calcification ya kamora ho kenya, mme tsa beha kotsing nako e telele ya dihlahiswa.

Ho sebetsana le phephetso ena, phuputso ya moraorao e phatlaladitsweng ka Mmesa 2025 e hlahisitse tharollo e ntjha ya kalafo ya ho thibela calcification (lebitso la sehlahiswa: Periborn), e fihlellang kgatelopele e babatsehang.

1. Lintlafatso tsa Theknoloji ea Bohlokoa:

Tharollo ena e hlahisa lintlafatso tse 'maloa tsa bohlokoa ts'ebetsong ea setso ea ho hokahanya glutaraldehyde:

Ho hokahanya ha Solvent ea Organic:
Ho kopanya Glutaraldehyde ho etsoa ka har'a solvent ea organic e entsoeng ka 75% ethanol + 5% octanol. Mokhoa ona o thusa ho tlosa phospholipids ea lisele ka katleho nakong ea ho kopanya - phospholipids e le libaka tsa mantlha tsa nucleation bakeng sa calcification.

Moemeli oa ho Tlatsa Sebaka:

Kamora ho kopanya, polyethylene glycol (PEG) e sebediswa e le sesebediswa sa ho tlatsa sebaka, e kenella dikgeong tse pakeng tsa difaeba tsa collagen. Sena se sireletsa dibaka tsa nucleation tsa dikristale tsa hydroxyapatite mme se thibela ho kenella ha calcium le phospholipids ho tswa plasma ya moamoheli.

Ho Tiisoa ha Terminal:

Qetellong, kalafo ka glycine e thibela lihlopha tse setseng tsa aldehyde tse sa sebetseng, ka hona e felisa ntlha e 'ngoe ea bohlokoa e bakang calcification le cytotoxicity.

2. Liphetho tse Hlollang tsa Bongaka:

Theknoloji ena e sebelisitsoe ho scaffold ea likhomo e bitsoang "Periborn." Phuputso ea kliniki e latelang bakuli ba 352 ba lilemo tse fetang 9 e bontšitse tokoloho ea ts'ebetso hape ka lebaka la mathata a amanang le sehlahisoa a fihlang ho 95.4%, e tiisang katleho ea leano lena le lecha la ho thibela calcification le ho tšoarella ha lona ho ikhethang nako e telele.

Bohlokoa ba Katleho ena:

Ha e sebetsane feela le phephetso ea nako e telele lefapheng la li-valve tsa bioprosthetic, e eketsang bophelo ba sehlahisoa, empa hape e kenya matla a macha ts'ebelisong ea glutaraldehyde linthong tsa bongaka tsa maemo a holimo.