Lefapheng la li-implants tsa pelo, glutaraldehyde e 'nile ea sebelisoa ka nako e telele ho phekola lisele tsa liphoofolo (tse kang bovine pericardium) bakeng sa tlhahiso ea li-valve tsa bioprosthetic. Leha ho le joalo, lihlopha tse setseng tsa aldehyde tse sa lefelloeng ho tloha lits'ebetsong tsa setso li ka lebisa ho calcification ea post-implantation, e behang kotsing ho tšoarella ha nako e telele ea lihlahisoa.
Ho sebetsana le phephetso ena, phuputso ea morao-rao e phatlalalitsoeng ka Mmesa 2025 e hlahisitse tharollo ea kalafo ea anti-calcification (lebitso la sehlahisoa: Periborn), e fihletseng tsoelo-pele e makatsang.
Lintlafatso tsa 1.Core Technological:
Tharollo ena e hlahisa lintlafatso tse 'maloa tsa bohlokoa ts'ebetsong ea li-cross-link tsa glutaraldehyde:
Organic Solvent Cross-Linking:
Glutaraldehyde cross-linking e etsoa ka motsoako oa motsoako o entsoeng ka 75% ethanol + 5% octanol. Mokhoa ona o thusa ka katleho ho tlosa phospholipids ea lisele nakong ea li-cross-link-phospholipids e le libaka tse ka sehloohong tsa nucleation bakeng sa calcification.
Moemeli oa ho Tlatsa Sebaka:
Ka mor'a ho hokahanya, polyethylene glycol (PEG) e sebelisoa e le moemeli oa ho tlatsa sebaka, ho kenya likheo pakeng tsa likhoele tsa collagen. Sena ka bobeli se sireletsa libaka tsa nucleation tsa likristale tsa hydroxyapatite le ho thibela ho kenella ha calcium le phospholipids ho tsoa ho plasma e amohelang.
Ho Tiisa Terminal:
Qetellong, phekolo ea glycine e fokotsa lihlopha tse setseng, tse sebetsang hantle tsa aldehyde, ka hona ho felisa ntlha e 'ngoe ea bohlokoa e bakang calcification le cytotoxicity.
2. Liphetho tse Hloahloa tsa Kliniki:
Theknoloji ena e sebelisitsoe ho scaffold ea bovine pericardial e bitsoang "Periborn." Phuputso ea morao-rao ea kliniki e akaretsang bakuli ba 352 ka lilemo tse 9 e bontšitse tokoloho ea ho sebetsa hape ka lebaka la litaba tse amanang le lihlahisoa tse ka holimo ho 95.4%, ho tiisa katleho ea leano lena le lecha le khahlanong le calcification le ho tšoarella ha eona nako e telele.
Bohlokoa ba Khatelo-pele ena:
Ha e sebetsane feela le phephetso ea nako e telele tšimong ea li-valve tsa bioprosthetic, ho lelefatsa bophelo ba sehlahisoa, empa hape e kenya matla a macha ts'ebelisong ea glutaraldehyde ka thepa ea boleng bo holimo.
Nako ea poso: Oct-28-2025